Professor Ruiliang Bai from Zhejiang University Visited APM

    On April 9, 2025, Professor Ruiliang Bai from the School of Medicine of Zhejiang University was invited by the Ultra-sensitive Magnetic Resonance Group and gave an academic report titled "Integrated Diagnosis and Treatment of Gliomas Based on Magnetic Resonance Imaging Technology of Aquaporin" in Conference Room 1819 of Building M. This report was chaired by Researcher Haidong Li.

    Professor Ruiliang Bai is a Principal Investigator (PI) of the Frontier Science Center for Brain and Brain-Machine Integration of the Ministry of Education and the National Key Laboratory of Brain-Machine Intelligence. He is mainly engaged in the research on magnetic resonance imaging technology of cerebral circulation function and its clinical transformation, and has achieved a series of results in aspects such as non-invasive blood-brain barrier assessment technology, quantitative measurement technology of aquaporin 4, and visualization technology of the glymphatic system. In the past five years, he has published more than 30 SCI papers as the first author or corresponding author (including Nature Biomedical Engineering, Fluids and Barriers of the CNS, Medical Image Analysis, Neuroimage, etc.), more than 20 other SCI papers, and has been authorized more than 10 invention patents, including 3 US patents.

    In the report, Professor Bai first introduced the important role of aquaporin 4 (AQP4) in the central nervous system and the fate of glioma cells. Secondly, Professor Bai introduced a whole-tumor AQP4 magnetic resonance imaging technology, which realized non-invasive, high-resolution and quantitative imaging of AQP4 in gliomas, successfully revealed the spatial heterogeneity of AQP4 expression in gliomas, and preliminarily found that the new technology can indicate the sensitivity of gliomas to radiotherapy and chemotherapy. This technology can be realized under the condition of conventional 3T and various magnetic field strengths, and can be completed with the cooperation of conventional clinical contrast agents without additional scanning time and cost, showing strong universality, and is expected to provide an effective imaging tool for the individualized and precise diagnosis and treatment of gliomas. Finally, Professor Bai introduced a series of research and applications of this technology at the cellular, in vivo and clinical levels.

    After the report, Professor Bai had an in-depth exchange with the teachers and students on site, further deepening everyone's understanding of the magnetic resonance imaging technology based on aquaporin.